The tell-tale sign of Chickenpox: An itchy rash that turns into fluid-filled blisters. What is Chickenpox? Chickenpox (Varicella) is a highly contagious viral infection characterized by an itchy, blister-like skin rash and flu-like symptoms. The Virus: It is caused by the Varicella-Zoster virus. Once the initial infection heals, the virus stays dormant (inactive) in your nerve tissues and can reactivate decades later as a painful condition known as Shingles . The 3 Stages of the Rash The chickenpox rash typically appears 10 to 21 days after exposure to the virus. It evolves through three distinct phases, often with all three stages appearing on the body simultaneously as new bumps break out while older ones heal. Stage 1: Papules (Days 1-2). Raised pink or red bumps (papules) break out over several days. Stage 2: Vesicles (Days 2-4). The bumps turn into small, fluid-filled blisters (vesicles). These a...