Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also called major depression, major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical problems. You may have trouble doing normal day-to-day activities, and depression may make you feel as if life isn't worth living.
More than just a bout of the blues, depression isn't a weakness, nor is it something that you can simply \"snap out\" of. Depression may require long-term treatment. But don't get discouraged. Most people with depression feel better with medication, psychological counseling or both. Other treatments also may help.
SYMPTOMS
Although depression may occur only one time during your life, usually people have multiple episodes of depression. During these episodes, symptoms occur most of the day, nearly every day and may include:
Feelings of sadness, emptiness or unhappinessAngry outbursts, irritability or frustration, even over small mattersLoss of interest or pleasure in normal activities, such as sexSleep disturbances, including insomnia or sleeping too muchTiredness and lack of energy, so that even small tasks take extra effortChanges in appetite — often reduced appetite and weight loss, but increased cravings for food and weight gain in some peopleAnxiety, agitation or restlessness — for example, excessive worrying, pacing, hand-wringing or an inability to sit stillSlowed thinking, speaking or body movementsFeelings of worthlessness or guilt, fixating on past failures or blaming yourself for things that are not your responsibilityTrouble thinking, concentrating, making decisions and remembering thingsFrequent thoughts of death, suicidal thoughts, suicide attempts or suicideUnexplained physical problems, such as back pain or headaches
For some people, depression symptoms are so severe that it's obvious something isn't right. Other people feel generally miserable or unhappy without really knowing why.
Types of depression
Depression affects each person in different ways, so symptoms caused by depression vary from person to person. To clarify the type of depression you have, your doctor may add information to your depression diagnosis called a specifier. Specifiers include having depression with specific features, such as:
Anxious distress — unusual restlessness or worry about possible events or loss of controlMixed features — simultaneous depression and mania, which includes elevated self-esteem, talking too much, and racing thoughts and ideasMelancholic features — severe depression with a profound lack of response to something that used to bring pleasure, associated with early morning awakening, worsened mood in the morning, significant changes in appetite, and feelings of guilt, agitation or sluggishnessAtypical features — ability to be cheered by happy events, increased appetite, little need for sleep, sensitivity to rejection, and a heavy feeling in arms or legsPsychotic features — depression accompanied by delusions or hallucinations, which may involve themes of personal inadequacy or negative themesCatatonia — includes motor activity that involves either uncontrollable and purposeless movement or fixed and inflexible posturePeripartum onset — occurs during pregnancy or in the weeks or months after delivery (postpartum)Seasonal pattern — related to changes in seasons and diminished exposure to sunlight
Depression symptoms in children and teens
Common symptoms of depression in children and teens are similar to those of adults, but there can be some differences.
In younger children, symptoms of depression may include sadness, irritability, clinginess, worry, aches and pains, refusing to go to school, or being underweight.In teens, symptoms may include sadness, irritability, feeling negative and worthless, anger, poor performance or poor attendance at school, feeling misunderstood and extremely sensitive, using drugs or alcohol, eating or sleeping too much, self-harm, loss of interest in normal activities, and avoidance of social interaction.Depression may occur with other mental health conditions, such as anxiety, eating disorders, substance abuse or attention-deficit/hyperactivity disorder (ADHD).
Depression symptoms in older adults
Depression is not a normal part of growing older and it should never be taken lightly. Unfortunately, depression often goes undiagnosed and untreated in older adults, and they may feel reluctant to seek help. Symptoms of depression may be different or less obvious in older adults, including:
Memory difficulties or personality changesFatigue, loss of appetite, sleep problems, aches or loss of interest in sex, which are not caused by a medical condition or medicationOften wanting to stay at home, rather than going out to socialize or doing new thingsSuicidal thinking or feelings, especially in older men
CAUSES
It's not known exactly what causes depression. As with many mental disorders, a variety of factors may be involved, such as:
Biological differences. People with depression appear to have physical changes in their brains. The significance of these changes is still uncertain, but may eventually help pinpoint causes.Brain chemistry. Neurotransmitters are naturally occurring brain chemicals that likely play a role in depression. When these chemicals are out of balance, it may be associated with depressive symptoms.Hormones. Changes in the body's balance of hormones may be involved in causing or triggering depression. Hormone changes can result from thyroid problems, menopause or a number of other conditions.Inherited traits. Depression is more common in people whose biological (blood) relatives also have this condition. Researchers are trying to find genes that may be involved in causing depression.Life events. Traumatic events such as the death or loss of a loved one, financial problems, high stress, or childhood trauma can trigger depression in some people.
COMPLICATIONS
Depression is a serious disorder that can take a terrible toll on individuals and families. Untreated depression can result in emotional, behavioral and health problems that affect every area of your life. Complications associated with depression may include:
Excess weight or obesity, which can lead to heart disease and diabetesAlcohol or substance abuseAnxiety, panic disorder or social phobiaFamily conflicts, relationship difficulties, and work or school problemsSocial isolationSuicidal feelings, suicide attempts or suicideSelf-mutilation, such as cuttingPremature death from other medical conditions
DIAGNOSIS
These exams and tests can help rule out other problems that could be causing your symptoms, pinpoint a diagnosis and check for any related complications:
Physical exam. Your doctor may do a physical exam and ask in-depth questions about your health. In some cases, depression may be linked to an underlying physical health problem.Lab tests. For example, your doctor may do a blood test called a complete blood count (CBC) or test your thyroid to make sure it's functioning properly.Psychological evaluation. To check for signs of depression, your doctor or mental health provider asks about your symptoms, thoughts, feelings and behavior patterns. Your doctor may have you fill out a questionnaire to help answer these questions.
Diagnostic criteria for depression
To be diagnosed with major depression, you must meet the symptom criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM), published by the American Psychiatric Association. This manual is used by mental health providers to diagnose mental conditions and by insurance companies to reimburse for treatment.
For major depression, you must have five or more of the following symptoms over a two-week period, most of the day, nearly every day. At least one of the symptoms must be either a depressed mood or a loss of interest or pleasure. Other symptoms may include:
Depressed mood, such as feeling sad, empty or tearful (in children and teens, depressed mood can appear as constant irritability)Significantly diminished interest or feeling no pleasure in all — or almost all — activitiesSignificant weight loss when not dieting, weight gain, or decrease or increase in appetite (in children, failure to gain weight as expected)Insomnia or increased desire to sleepEither restlessness or slowed behavior that can be observed by othersFatigue or loss of energyFeelings of worthlessness, or excessive or inappropriate guiltTrouble making decisions, or trouble thinking or concentratingRecurrent thoughts of death or suicide, or a suicide attempt
Your symptoms must be severe enough to cause noticeable problems in day-to-day activities, such as work, school, social activities or relationships with others. Symptoms can be based on your own feelings or may be based on the observations of someone else.
Other conditions that cause depression symptoms
There are several other conditions with symptoms that can include depression. It's important to get an accurate diagnosis so you can get appropriate treatment. Your doctor or mental health provider's evaluation will help determine if your symptoms of depression are caused by a specific type of depression or another condition, such as:
Adjustment disorder. An adjustment disorder is a severe emotional reaction to a difficult event in your life. It's a type of stress-related mental illness that may affect your feelings, thoughts and behavior.Bipolar disorder. This mood disorder is characterized by mood swings that range from highs to lows. It's sometimes difficult to distinguish between bipolar disorder and depression.Cyclothymic disorder. Cyclothymic (sy-kloe-THIE-mik) disorder involves highs and lows that are milder than those of bipolar disorder.Persistent depressive disorder. Sometimes called dysthymia (dis-THIE-me-uh), this is a less severe but more chronic form of depression. While it's usually not disabling, persistent depressive disorder can prevent you from functioning normally in your daily routine and from living life to its fullest.Premenstrual dysphoric disorder. This involves depression symptoms associated with hormone changes that begin a week before and improve within a few days after the onset of your period, and are minimal or gone after completion of your period.Attention-deficit/hyperactivity disorder (ADHD). Children with ADHD can demonstrate irritability without sadness or loss of interest. However, major depression can occur with ADHD.
Make sure you understand what type of depression you have so that you can learn more about your specific situation and treatment options.
TREATMENT
Numerous depression treatments are available. Medications and psychological counseling (psychotherapy) are very effective for most people.
Your primary care doctor or psychiatrist can prescribe medications to relieve depression symptoms. However, many people with depression also benefit from seeing a psychologist or other mental health counselor.
If you have severe depression, you may need a hospital stay, or you may need to participate in an outpatient treatment program until your symptoms improve.
Here's a closer look at depression treatment options.
Medications
Many types of antidepressant medications are available to treat depression, including those below. Discuss possible major side effects with your doctor or pharmacist.
Selective serotonin reuptake inhibitors (SSRIs). Doctors often start by prescribing an SSRI. These medications are safer and generally cause fewer bothersome side effects than do other types of antidepressants. SSRIs include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro).Serotonin and norepinephrine reuptake inhibitors (SNRIs). Examples of SNRI medications include duloxetine (Cymbalta), venlafaxine (Effexor XR) and desvenlafaxine (Pristiq).Norepinephrine and dopamine reuptake inhibitors (NDRIs). Bupropion (Wellbutrin) falls into this category. It's one of the few antidepressants not frequently associated with sexual side effects.Atypical antidepressants. These medications don't fit neatly into any of the other antidepressant categories. They include trazodone and mirtazapine (Remeron). Both are sedating and usually taken in the evening. A newer medication called vilazodone (Viibryd) is thought to have a low risk of sexual side effects.Tricyclic antidepressants. Tricyclic antidepressants — such as imipramine (Tofranil) and nortriptyline (Pamelor) — tend to cause more severe side effects than do newer antidepressants. So tricyclics generally aren't prescribed unless you've tried an SSRI first without improvement.Monoamine oxidase inhibitors (MAOIs). MAOIs — such as tranylcypromine (Parnate) and phenelzine (Nardil) — may be prescribed, typically when other medications haven't worked, because they can have serious side effects. Using MAOIs requires a strict diet because of dangerous (or even deadly) interactions with foods ? such as certain cheeses, pickles and wines ? and some medications including birth control pills, decongestants and certain herbal supplements. Selegiline (Emsam), a newer MAOI that you stick on your skin as a patch, may cause fewer side effects than other MAOIs do. These medications can't be combined with SSRIs.Other medications. Other medications may be added to an antidepressant to enhance antidepressant effects. Your doctor may recommend combining two antidepressants or medications such as mood stabilizers or antipsychotics. Anti-anxiety and stimulant medications might also be added for short-term use.
Finding the right medication
If a family member has responded well to an antidepressant, it may be one that could help you. Or you may need to try several medications before you find one that works. This requires patience, as some medications need several weeks or longer to take full effect and for side effects to ease as your body adjusts.
Don't stop taking an antidepressant without talking to your doctor first. Antidepressants aren't considered addictive, but sometimes physical dependence, which is different from addiction, can occur. Stopping treatment abruptly or missing several doses can cause withdrawal-like symptoms, and quitting suddenly may cause a sudden worsening of depression. Work with your doctor to gradually and safely decrease your dose.
Inherited traits play a role in how antidepressants affect you. In some cases, where available, results of genetic tests (done by blood test or cheek swab) may offer clues about how your body may respond to a particular antidepressant. The study of how genes affect a person's response to drugs is called pharmacogenomics. However, other variables besides genetics can affect your response to medication.
Antidepressants and pregnancy
If you're pregnant or breast-feeding, some antidepressants may pose an increased health risk to your unborn child or nursing child. Talk to your doctor if you become pregnant or are planning on becoming pregnant.
Antidepressants and increased suicide risk
Most antidepressants are generally safe, but the FDA requires that all antidepressants carry black box warnings, the strictest warnings for prescriptions. In some cases, children, teenagers and young adults under 25 may have an increase in suicidal thoughts or behavior when taking antidepressants, especially in the first few weeks after starting or when the dose is changed.
Anyone taking an antidepressant should be watched closely for worsening depression or unusual behavior. If you or someone you know has suicidal thoughts when taking an antidepressant, immediately contact your doctor or get emergency help.
Keep in mind that antidepressants are more likely to reduce suicide risk in the long run by improving mood.
Psychotherapy
Psychotherapy is a general term for treating depression by talking about your condition and related issues with a mental health provider. Psychotherapy is also known as talk therapy, counseling or psychosocial therapy.
Different types of psychotherapy can be effective for depression, such as cognitive behavioral therapy, interpersonal therapy, dialectic behavioral therapy, acceptance and commitment therapy, and mindfulness techniques. These therapies can help you:
Adjust to a crisis or other current difficultyIdentify negative beliefs and behaviors and replace them with healthy, positive onesExplore relationships and experiences, and develop positive interactions with othersFind better ways to cope and solve problemsIdentify issues that contribute to your depression and change behaviors that make it worseRegain a sense of satisfaction and control in your life and help ease depression symptoms, such as hopelessness and angerLearn to set realistic goals for your lifeDevelop the ability to tolerate and accept distress using healthier behaviors
Hospitalization and residential treatment programs
In some people, depression is so severe that a hospital stay is needed. Inpatient hospitalization may be necessary if you can't care for yourself properly or when you're in immediate danger of harming yourself or someone else. Psychiatric treatment at a hospital can help keep you calm and safe until your mood improves.
Partial hospitalization or day treatment programs also may help some people. These programs provide the outpatient support and counseling you need while you get symptoms under control.
Other treatment options
For some people, other procedures may be suggested:
Electroconvulsive therapy (ECT). In ECT, electrical currents are passed through the brain. This procedure is thought to affect levels of neurotransmitters in your brain and typically offers immediate relief of even severe depression when other treatments don't work. Physical side effects, such as headache, are tolerable. Some people also have memory loss, which is usually temporary. ECT is usually used for people who don't get better with medications, can't take antidepressants for health reasons or are at high risk of suicide.Transcranial magnetic stimulation (TMS). TMS may be an option for those who haven't responded to antidepressants. During TMS, you sit in a reclining chair with a treatment coil placed against your scalp. The coil sends brief magnetic pulses to stimulate nerve cells in your brain that are involved in mood regulation and depression. Typically, you'll have five treatments each week for up to six weeks.
More than just a bout of the blues, depression isn't a weakness, nor is it something that you can simply \"snap out\" of. Depression may require long-term treatment. But don't get discouraged. Most people with depression feel better with medication, psychological counseling or both. Other treatments also may help.
SYMPTOMS
Although depression may occur only one time during your life, usually people have multiple episodes of depression. During these episodes, symptoms occur most of the day, nearly every day and may include:
Feelings of sadness, emptiness or unhappinessAngry outbursts, irritability or frustration, even over small mattersLoss of interest or pleasure in normal activities, such as sexSleep disturbances, including insomnia or sleeping too muchTiredness and lack of energy, so that even small tasks take extra effortChanges in appetite — often reduced appetite and weight loss, but increased cravings for food and weight gain in some peopleAnxiety, agitation or restlessness — for example, excessive worrying, pacing, hand-wringing or an inability to sit stillSlowed thinking, speaking or body movementsFeelings of worthlessness or guilt, fixating on past failures or blaming yourself for things that are not your responsibilityTrouble thinking, concentrating, making decisions and remembering thingsFrequent thoughts of death, suicidal thoughts, suicide attempts or suicideUnexplained physical problems, such as back pain or headaches
For some people, depression symptoms are so severe that it's obvious something isn't right. Other people feel generally miserable or unhappy without really knowing why.
Types of depression
Depression affects each person in different ways, so symptoms caused by depression vary from person to person. To clarify the type of depression you have, your doctor may add information to your depression diagnosis called a specifier. Specifiers include having depression with specific features, such as:
Anxious distress — unusual restlessness or worry about possible events or loss of controlMixed features — simultaneous depression and mania, which includes elevated self-esteem, talking too much, and racing thoughts and ideasMelancholic features — severe depression with a profound lack of response to something that used to bring pleasure, associated with early morning awakening, worsened mood in the morning, significant changes in appetite, and feelings of guilt, agitation or sluggishnessAtypical features — ability to be cheered by happy events, increased appetite, little need for sleep, sensitivity to rejection, and a heavy feeling in arms or legsPsychotic features — depression accompanied by delusions or hallucinations, which may involve themes of personal inadequacy or negative themesCatatonia — includes motor activity that involves either uncontrollable and purposeless movement or fixed and inflexible posturePeripartum onset — occurs during pregnancy or in the weeks or months after delivery (postpartum)Seasonal pattern — related to changes in seasons and diminished exposure to sunlight
Depression symptoms in children and teens
Common symptoms of depression in children and teens are similar to those of adults, but there can be some differences.
In younger children, symptoms of depression may include sadness, irritability, clinginess, worry, aches and pains, refusing to go to school, or being underweight.In teens, symptoms may include sadness, irritability, feeling negative and worthless, anger, poor performance or poor attendance at school, feeling misunderstood and extremely sensitive, using drugs or alcohol, eating or sleeping too much, self-harm, loss of interest in normal activities, and avoidance of social interaction.Depression may occur with other mental health conditions, such as anxiety, eating disorders, substance abuse or attention-deficit/hyperactivity disorder (ADHD).
Depression symptoms in older adults
Depression is not a normal part of growing older and it should never be taken lightly. Unfortunately, depression often goes undiagnosed and untreated in older adults, and they may feel reluctant to seek help. Symptoms of depression may be different or less obvious in older adults, including:
Memory difficulties or personality changesFatigue, loss of appetite, sleep problems, aches or loss of interest in sex, which are not caused by a medical condition or medicationOften wanting to stay at home, rather than going out to socialize or doing new thingsSuicidal thinking or feelings, especially in older men
CAUSES
It's not known exactly what causes depression. As with many mental disorders, a variety of factors may be involved, such as:
Biological differences. People with depression appear to have physical changes in their brains. The significance of these changes is still uncertain, but may eventually help pinpoint causes.Brain chemistry. Neurotransmitters are naturally occurring brain chemicals that likely play a role in depression. When these chemicals are out of balance, it may be associated with depressive symptoms.Hormones. Changes in the body's balance of hormones may be involved in causing or triggering depression. Hormone changes can result from thyroid problems, menopause or a number of other conditions.Inherited traits. Depression is more common in people whose biological (blood) relatives also have this condition. Researchers are trying to find genes that may be involved in causing depression.Life events. Traumatic events such as the death or loss of a loved one, financial problems, high stress, or childhood trauma can trigger depression in some people.
COMPLICATIONS
Depression is a serious disorder that can take a terrible toll on individuals and families. Untreated depression can result in emotional, behavioral and health problems that affect every area of your life. Complications associated with depression may include:
Excess weight or obesity, which can lead to heart disease and diabetesAlcohol or substance abuseAnxiety, panic disorder or social phobiaFamily conflicts, relationship difficulties, and work or school problemsSocial isolationSuicidal feelings, suicide attempts or suicideSelf-mutilation, such as cuttingPremature death from other medical conditions
DIAGNOSIS
These exams and tests can help rule out other problems that could be causing your symptoms, pinpoint a diagnosis and check for any related complications:
Physical exam. Your doctor may do a physical exam and ask in-depth questions about your health. In some cases, depression may be linked to an underlying physical health problem.Lab tests. For example, your doctor may do a blood test called a complete blood count (CBC) or test your thyroid to make sure it's functioning properly.Psychological evaluation. To check for signs of depression, your doctor or mental health provider asks about your symptoms, thoughts, feelings and behavior patterns. Your doctor may have you fill out a questionnaire to help answer these questions.
Diagnostic criteria for depression
To be diagnosed with major depression, you must meet the symptom criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM), published by the American Psychiatric Association. This manual is used by mental health providers to diagnose mental conditions and by insurance companies to reimburse for treatment.
For major depression, you must have five or more of the following symptoms over a two-week period, most of the day, nearly every day. At least one of the symptoms must be either a depressed mood or a loss of interest or pleasure. Other symptoms may include:
Depressed mood, such as feeling sad, empty or tearful (in children and teens, depressed mood can appear as constant irritability)Significantly diminished interest or feeling no pleasure in all — or almost all — activitiesSignificant weight loss when not dieting, weight gain, or decrease or increase in appetite (in children, failure to gain weight as expected)Insomnia or increased desire to sleepEither restlessness or slowed behavior that can be observed by othersFatigue or loss of energyFeelings of worthlessness, or excessive or inappropriate guiltTrouble making decisions, or trouble thinking or concentratingRecurrent thoughts of death or suicide, or a suicide attempt
Your symptoms must be severe enough to cause noticeable problems in day-to-day activities, such as work, school, social activities or relationships with others. Symptoms can be based on your own feelings or may be based on the observations of someone else.
Other conditions that cause depression symptoms
There are several other conditions with symptoms that can include depression. It's important to get an accurate diagnosis so you can get appropriate treatment. Your doctor or mental health provider's evaluation will help determine if your symptoms of depression are caused by a specific type of depression or another condition, such as:
Adjustment disorder. An adjustment disorder is a severe emotional reaction to a difficult event in your life. It's a type of stress-related mental illness that may affect your feelings, thoughts and behavior.Bipolar disorder. This mood disorder is characterized by mood swings that range from highs to lows. It's sometimes difficult to distinguish between bipolar disorder and depression.Cyclothymic disorder. Cyclothymic (sy-kloe-THIE-mik) disorder involves highs and lows that are milder than those of bipolar disorder.Persistent depressive disorder. Sometimes called dysthymia (dis-THIE-me-uh), this is a less severe but more chronic form of depression. While it's usually not disabling, persistent depressive disorder can prevent you from functioning normally in your daily routine and from living life to its fullest.Premenstrual dysphoric disorder. This involves depression symptoms associated with hormone changes that begin a week before and improve within a few days after the onset of your period, and are minimal or gone after completion of your period.Attention-deficit/hyperactivity disorder (ADHD). Children with ADHD can demonstrate irritability without sadness or loss of interest. However, major depression can occur with ADHD.
Make sure you understand what type of depression you have so that you can learn more about your specific situation and treatment options.
TREATMENT
Numerous depression treatments are available. Medications and psychological counseling (psychotherapy) are very effective for most people.
Your primary care doctor or psychiatrist can prescribe medications to relieve depression symptoms. However, many people with depression also benefit from seeing a psychologist or other mental health counselor.
If you have severe depression, you may need a hospital stay, or you may need to participate in an outpatient treatment program until your symptoms improve.
Here's a closer look at depression treatment options.
Medications
Many types of antidepressant medications are available to treat depression, including those below. Discuss possible major side effects with your doctor or pharmacist.
Selective serotonin reuptake inhibitors (SSRIs). Doctors often start by prescribing an SSRI. These medications are safer and generally cause fewer bothersome side effects than do other types of antidepressants. SSRIs include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro).Serotonin and norepinephrine reuptake inhibitors (SNRIs). Examples of SNRI medications include duloxetine (Cymbalta), venlafaxine (Effexor XR) and desvenlafaxine (Pristiq).Norepinephrine and dopamine reuptake inhibitors (NDRIs). Bupropion (Wellbutrin) falls into this category. It's one of the few antidepressants not frequently associated with sexual side effects.Atypical antidepressants. These medications don't fit neatly into any of the other antidepressant categories. They include trazodone and mirtazapine (Remeron). Both are sedating and usually taken in the evening. A newer medication called vilazodone (Viibryd) is thought to have a low risk of sexual side effects.Tricyclic antidepressants. Tricyclic antidepressants — such as imipramine (Tofranil) and nortriptyline (Pamelor) — tend to cause more severe side effects than do newer antidepressants. So tricyclics generally aren't prescribed unless you've tried an SSRI first without improvement.Monoamine oxidase inhibitors (MAOIs). MAOIs — such as tranylcypromine (Parnate) and phenelzine (Nardil) — may be prescribed, typically when other medications haven't worked, because they can have serious side effects. Using MAOIs requires a strict diet because of dangerous (or even deadly) interactions with foods ? such as certain cheeses, pickles and wines ? and some medications including birth control pills, decongestants and certain herbal supplements. Selegiline (Emsam), a newer MAOI that you stick on your skin as a patch, may cause fewer side effects than other MAOIs do. These medications can't be combined with SSRIs.Other medications. Other medications may be added to an antidepressant to enhance antidepressant effects. Your doctor may recommend combining two antidepressants or medications such as mood stabilizers or antipsychotics. Anti-anxiety and stimulant medications might also be added for short-term use.
Finding the right medication
If a family member has responded well to an antidepressant, it may be one that could help you. Or you may need to try several medications before you find one that works. This requires patience, as some medications need several weeks or longer to take full effect and for side effects to ease as your body adjusts.
Don't stop taking an antidepressant without talking to your doctor first. Antidepressants aren't considered addictive, but sometimes physical dependence, which is different from addiction, can occur. Stopping treatment abruptly or missing several doses can cause withdrawal-like symptoms, and quitting suddenly may cause a sudden worsening of depression. Work with your doctor to gradually and safely decrease your dose.
Inherited traits play a role in how antidepressants affect you. In some cases, where available, results of genetic tests (done by blood test or cheek swab) may offer clues about how your body may respond to a particular antidepressant. The study of how genes affect a person's response to drugs is called pharmacogenomics. However, other variables besides genetics can affect your response to medication.
Antidepressants and pregnancy
If you're pregnant or breast-feeding, some antidepressants may pose an increased health risk to your unborn child or nursing child. Talk to your doctor if you become pregnant or are planning on becoming pregnant.
Antidepressants and increased suicide risk
Most antidepressants are generally safe, but the FDA requires that all antidepressants carry black box warnings, the strictest warnings for prescriptions. In some cases, children, teenagers and young adults under 25 may have an increase in suicidal thoughts or behavior when taking antidepressants, especially in the first few weeks after starting or when the dose is changed.
Anyone taking an antidepressant should be watched closely for worsening depression or unusual behavior. If you or someone you know has suicidal thoughts when taking an antidepressant, immediately contact your doctor or get emergency help.
Keep in mind that antidepressants are more likely to reduce suicide risk in the long run by improving mood.
Psychotherapy
Psychotherapy is a general term for treating depression by talking about your condition and related issues with a mental health provider. Psychotherapy is also known as talk therapy, counseling or psychosocial therapy.
Different types of psychotherapy can be effective for depression, such as cognitive behavioral therapy, interpersonal therapy, dialectic behavioral therapy, acceptance and commitment therapy, and mindfulness techniques. These therapies can help you:
Adjust to a crisis or other current difficultyIdentify negative beliefs and behaviors and replace them with healthy, positive onesExplore relationships and experiences, and develop positive interactions with othersFind better ways to cope and solve problemsIdentify issues that contribute to your depression and change behaviors that make it worseRegain a sense of satisfaction and control in your life and help ease depression symptoms, such as hopelessness and angerLearn to set realistic goals for your lifeDevelop the ability to tolerate and accept distress using healthier behaviors
Hospitalization and residential treatment programs
In some people, depression is so severe that a hospital stay is needed. Inpatient hospitalization may be necessary if you can't care for yourself properly or when you're in immediate danger of harming yourself or someone else. Psychiatric treatment at a hospital can help keep you calm and safe until your mood improves.
Partial hospitalization or day treatment programs also may help some people. These programs provide the outpatient support and counseling you need while you get symptoms under control.
Other treatment options
For some people, other procedures may be suggested:
Electroconvulsive therapy (ECT). In ECT, electrical currents are passed through the brain. This procedure is thought to affect levels of neurotransmitters in your brain and typically offers immediate relief of even severe depression when other treatments don't work. Physical side effects, such as headache, are tolerable. Some people also have memory loss, which is usually temporary. ECT is usually used for people who don't get better with medications, can't take antidepressants for health reasons or are at high risk of suicide.Transcranial magnetic stimulation (TMS). TMS may be an option for those who haven't responded to antidepressants. During TMS, you sit in a reclining chair with a treatment coil placed against your scalp. The coil sends brief magnetic pulses to stimulate nerve cells in your brain that are involved in mood regulation and depression. Typically, you'll have five treatments each week for up to six weeks.
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